TruScreen utilises technology to detect pre-cancerous change, or cervical intraepithelial neoplasia (CIN), by optical and electrical measurements of cervical tissue.
A pen-like wand touches various spots on the cervix to pick up electrical and optical signals from the cervical tissue. A single use sensor with precision lens and electrodes is used to interface with the cervix and protect against cross-infection.
The TruScreen console collects the data and provides immediate results, enabling the physician to immediately plan appropriate patient care.
Unlike cytology, TruScreen does not only examine surface epithelial cells. Light at specific frequencies is transmitted through cervical tissue identifying changes in the basal and stromal layers. This includes increases in blood circulation and variations in blood vessels that occur with pre-cancerous change.
The TruScreen system also assesses the electrical properties and response of the tissue. The electrical measurements are stimulated by the delivery of a very small impulse (about one volt) in millisecond pulse sequences that repeat 14 times per second. The decay response curve will vary according to the capacitance of the tissue – a measurement of the ability of the tissue to either hold or dissipate a charge. Different tissue types and the properties of the tissue have different capacitance.
The console has a microcomputer to calculate these tissue differences, and the results are compared to an integrated database of 2,000 patients from wide geographic and ethnic backgrounds with differing histological diagnoses. A sophisticated proprietary algorithm framework has been developed to distinguish between normal and abnormal (cancerous and precancerous) tissue.